de Wardener H E, Mills I H, Clapham W F & Hayler C J. Studies on the efferent mechanism of the sodium diuresis which follows the administration of intravenous saline in the dog. Clin. Sci. 21:249-58, 1961
نویسنده
چکیده
Dogs loaded with sodium-retaining and antidiuretic hormones were given a rapid saline infusion intravenously. Increased sodium excretion occurred with lowered filtration rate and renal denervation. Cross circulation between infused and non-infused dogs suggested the presence of a natriuretic hormone with a short half-life. [The SCI® indicates that this paper has been cited over 300 times since 1961.]
منابع مشابه
Effect of thoracic cava obstruction on response of proximal tubule sodium reabsorption to saline infusion.
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Hormonal regulation of salt excretion and water balance by the kidneys is well documented. Before 1961, it was widely believed that the glomerular filtration rate and the steroid hormone aldosterone controlled sodium balance in the body. In 1961, deWardener et al. [de Wardener HE, Mills IH, Clapham WF, Hayter CJ (1961) Clin Sci 21:249-258] showed that when these two variables were controlled, t...
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تاریخ انتشار 2004